15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5[S]

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5[S]

The two oxylipins 7S,14S-dihydroxydocosahexaenoic acid (diHDHA) and 7S,17S-diHDHA [resolvin D5 (RvD5)] have been found in macrophages and infectious inflammatory exudates and are believed to function as specialized pro-resolving mediators (SPMs). Their biosynthesis is thought to proceed through sequ...

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Bibliographic Details
Main Authors: Steven C. Perry, Chakrapani Kalyanaraman, Benjamin E. Tourdot, William S. Conrad, Oluwayomi Akinkugbe, John Cody Freedman, Michael Holinstat, Matthew P. Jacobson, Theodore R. Holman
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Journal of Lipid Research
Subjects:
kinetics
docosahexaenoic acid
maresin
molecular modeling
platelets
mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520435862

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http://www.sciencedirect.com/science/article/pii/S0022227520435862

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