Developmental dynamics of voltage-gated sodium channel isoform expression in the human and mouse brain

Developmental dynamics of voltage-gated sodium channel isoform expression in the human and mouse brain

Abstract Background Genetic variants in the voltage-gated sodium channels SCN1A, SCN2A, SCN3A, and SCN8A are leading causes of epilepsy, developmental delay, and autism spectrum disorder. The mRNA splicing patterns of all four genes vary across development in the rodent brain, including mutually exc...

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Bibliographic Details
Main Authors: Lindsay Liang, Siavash Fazel Darbandi, Sirisha Pochareddy, Forrest O. Gulden, Michael C. Gilson, Brooke K. Sheppard, Atehsa Sahagun, Joon-Yong An, Donna M. Werling, John L. R. Rubenstein, Nenad Sestan, Kevin J. Bender, Stephan J. Sanders
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Genome Medicine
Subjects:
Isoform
Splicing
Voltage-gated sodium channel
Autism spectrum disorder
Intellectual disability
Developmental delay
Online Access:https://doi.org/10.1186/s13073-021-00949-0

Internet

https://doi.org/10.1186/s13073-021-00949-0

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