Mitochondrial aldehyde dehydrogenase-2 deficiency compromises therapeutic effect of ALDH bright cell on peripheral ischemia

Mitochondrial aldehyde dehydrogenase-2 deficiency compromises therapeutic effect of ALDH bright cell on peripheral ischemia

The autologous ALDH bright (ALDHbr) cell therapy for ischemic injury is clinically safe and effective, while the underlying mechanism remains elusive. Here, we demonstrated that the glycolysis dominant metabolism of ALDHbr cells is permissive to restore blood flow in an ischemic hind limb model comp...

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Bibliographic Details
Main Authors: Xiaolei Sun, Hong Zhu, Zhen Dong, Xiangwei Liu, Xin Ma, Shasha Han, Fei Lu, Peng Wang, Sanli Qian, Cong Wang, Cheng Shen, Xiaona Zhao, Yunzeng Zou, Junbo Ge, Aijun Sun
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Redox Biology
Subjects:
ALDH2
ALDHbr cells
Glycolysis
Ischemia injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717302835

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http://www.sciencedirect.com/science/article/pii/S2213231717302835

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