RNase L mediated protection from virus induced demyelination.
IFN-alpha/beta plays a critical role in limiting viral spread, restricting viral tropism and protecting mice from neurotropic coronavirus infection. However, the IFN-alpha/beta dependent mechanisms underlying innate anti-viral functions within the CNS are poorly understood. The role of RNase L in vi...
Main Authors: | Derek D C Ireland, Stephen A Stohlman, David R Hinton, Parul Kapil, Robert H Silverman, Roscoe A Atkinson, Cornelia C Bergmann |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-10-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC2745574?pdf=render |
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