Direct inhibition of T-cell responses by the Cryptococcus capsular polysaccharide glucuronoxylomannan.
The major virulence factor of the pathogenic fungi Cryptococcus neoformans and C. gattii is the capsule. Glucuronoxylomannan (GXM), the major component of the capsule, is a high-molecular-weight polysaccharide that is shed during cryptococcosis and can persist in patients after successful antifungal...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-11-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC1635532?pdf=render |