Induction of Mycobacterium Tuberculosis Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers

Induction of Mycobacterium Tuberculosis Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers

Mycolic acid (MA), a major lipid component of Mycobacterium tuberculosis (Mtb) cell wall, can be presented by the non-polymorphic antigen presenting molecule CD1b to T cells isolated from Mtb-infected individuals. These MA-specific CD1b-restricted T cells are cytotoxic, produce Th1 cytokines, and fo...

Full description

Bibliographic Details
Main Authors: Shaobin Shang, Dina Kats, Liang Cao, Eva Morgun, Diana Velluto, Ying He, Qichen Xu, Chyung-Ru Wang, Evan A. Scott
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
mycolic acid
T cells
CD1
lipid antigens
micelles
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02709/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02709/full

Similar Items