The role of Notch in the cardiovascular system: potential adverse effects of investigational Notch inhibitors

The role of Notch in the cardiovascular system: potential adverse effects of investigational Notch inhibitors

Targeting the Notch pathway is a new promising therapeutic approach for cancer patients. Inhibition of Notch is effective in the oncology setting because it causes a reduction of highly proliferative tumor cells and it inhibits survival of cancer stem cells which are considered responsible for tumor...

Full description

Bibliographic Details
Main Authors: Paola eRizzo, Donato eMele, Cristiana eCaliceti, Cinzia eFortini, Anthony George Clementz, Marco Bruno Morelli, Giorgio eAquila, Pietro eAmeri, Roberto eFerrari
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Oncology
Subjects:
cardiotoxicity
cancer therapy
cardiac remodelling
Notch inhibitors
endothelial dysfunctions
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00384/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00384/full

Similar Items