Evodiamine Stabilizes Topoisomerase I-DNA Cleavable Complex to Inhibit Topoisomerase I Activity

Evodiamine Stabilizes Topoisomerase I-DNA Cleavable Complex to Inhibit Topoisomerase I Activity

Evodiamine (EVO), an alkaloidal compound isolated from Evodia rutaecarpa (Juss.), has been reported to affect many physiological functions. Topoisomerase inhibitors have been developed in a variety of clinical applications. In the present study, we report the topoisomerase I (TopI) inhibitory activi...

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Bibliographic Details
Main Authors: Jau-Lang Hwang, Chiao-En Chen, Chun-Mao Lin, Chi-Ming Lee, Agnes L.-F. Chan, Wen-Shin Chang, Li-Min Chen
Format: Article
Language:English
Published: MDPI AG 2009-03-01
Series:Molecules
Subjects:
Evodiamine
Topoisomerase
Covalent complex
Online Access:http://www.mdpi.com/1420-3049/14/4/1342/

Internet

http://www.mdpi.com/1420-3049/14/4/1342/

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