The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy

The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy

Abstract Chimeric Antigen Receptor (CAR) immunotherapy utilizes genetically-engineered immune cells that express a unique cell surface receptor that combines tumor antigen specificity with immune cell activation. In recent clinical trials, the adoptive transfer of CAR-modified immune cells (includin...

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Bibliographic Details
Main Authors: Dongfang Liu, Saiaditya Badeti, Gianpietro Dotti, Jie-gen Jiang, He Wang, James Dermody, Patricia Soteropoulos, Deanna Streck, Raymond B. Birge, Chen Liu
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Cell Communication and Signaling
Subjects:
chimeric antigen receptor
immunotherapy
immunological synapse
and cancer
Online Access:http://link.springer.com/article/10.1186/s12964-020-00617-7

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http://link.springer.com/article/10.1186/s12964-020-00617-7

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