Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE

Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE

Abstract Background Forkhead box O3A (FOXOA3) and apolipoprotein E (APOE) are arguably the strongest gene candidates to influence human exceptional longevity (EL, i.e., being a centenarian), but inconsistency exists among cohorts. Epistasis, defined as the effect of one locus being dependent on the...

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Bibliographic Details
Main Authors: Noriyuki Fuku, Roberto Díaz-Peña, Yasumichi Arai, Yukiko Abe, Hirofumi Zempo, Hisashi Naito, Haruka Murakami, Motohiko Miyachi, Carlos Spuch, José A. Serra-Rexach, Enzo Emanuele, Nobuyoshi Hirose, Alejandro Lucia
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Genomics
Subjects:
Exceptional longevity
Centenarians
FOXO3A
FNDC5
APOE
Ageing
Online Access:http://link.springer.com/article/10.1186/s12864-017-4194-4

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http://link.springer.com/article/10.1186/s12864-017-4194-4

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