Synthetic CpG islands reveal DNA sequence determinants of chromatin structure

Synthetic CpG islands reveal DNA sequence determinants of chromatin structure

The mammalian genome is punctuated by CpG islands (CGIs), which differ sharply from the bulk genome by being rich in G + C and the dinucleotide CpG. CGIs often include transcription initiation sites and display ‘active’ histone marks, notably histone H3 lysine 4 methylation. In embryonic stem cells...

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Bibliographic Details
Main Authors: Elisabeth Wachter, Timo Quante, Cara Merusi, Aleksandra Arczewska, Francis Stewart, Shaun Webb, Adrian Bird
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-09-01
Series:eLife
Subjects:
DNA methylation
CpG island
histone modification
bivalent chromatin
Online Access:https://elifesciences.org/articles/03397

Internet

https://elifesciences.org/articles/03397

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