Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases.
Bacterial aromatic polyketides such as tetracycline and doxorubicin are a medicinally important class of natural products produced as secondary metabolites by actinomyces bacteria. Their backbones are derived from malonyl-CoA units by polyketide synthases (PKSs). The nascent polyketide chain is synt...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2004-02-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC340942?pdf=render |