Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy: Implications for Early Diagnosis and Translational Research in Alzheimer’s Disease

Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy: Implications for Early Diagnosis and Translational Research in Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized by neuronal loss and impaired synaptic transmission, ultimately leading to cognitive deficits. Early in the disease, the olfactory track seems most sensitive to tauopathy, while most plasticity studies focused on the hippocampal circuits. Functional network...

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Bibliographic Details
Main Authors: Abdallah Ahnaou, Daniela Rodriguez-Manrique, Ria Biermans, Sofie Embrechts, Nikolay V. Manyakov, Wilhelmus H. Drinkenburg
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
tau
neural oscillations
LTP
olfactory neural network
translational marker
Online Access:https://www.mdpi.com/1422-0067/21/15/5431

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https://www.mdpi.com/1422-0067/21/15/5431

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