Activating KIRs in Chronic Lymphoproliferative Disorder of NK cells: protection from viruses and disease induction?

Activating KIRs in Chronic Lymphoproliferative Disorder of NK cells: protection from viruses and disease induction?

Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin like receptors (KIRs) and their interactions with HLA class I molecules. As KIR expression in a given NK cell is genetically established, KIR repertoire perturbations reflect a dominance of discrete NK-cell subs...

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Bibliographic Details
Main Authors: Renato eZambello, Antonella eTeramo, Gregorio eBarilà, Cristina eGattazzo, Gianpietro eSemenzato
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Immunology
Subjects:
viral infections
CLPD-NK
Activating KIRs
NK cell licensing
Pathogenesis in NK disorders
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00072/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00072/full

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