Agonism of Prostaglandin E2 Receptor 4 Ameliorates Tubulointerstitial Injury in Nephrotoxic Serum Nephritis in Mice

Agonism of Prostaglandin E2 Receptor 4 Ameliorates Tubulointerstitial Injury in Nephrotoxic Serum Nephritis in Mice

Selectively targeting the E-type prostanoid receptor 4 (EP4) might be a new therapeutic option in the treatment of glomerulonephritis (GN), since the EP4 receptor is expressed on different immune cells, resident kidney cells, and endothelial cells, which are all involved in the pathogenesis of immun...

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Bibliographic Details
Main Authors: Ida Aringer, Katharina Artinger, Corinna Schabhüttl, Thomas Bärnthaler, Agnes A. Mooslechner, Andrijana Kirsch, Marion Pollheimer, Philipp Eller, Alexander R. Rosenkranz, Akos Heinemann, Kathrin Eller
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Journal of Clinical Medicine
Subjects:
EP4 receptor
PGE2
NTS
glomerulonephritis
lipid mediator
Online Access:https://www.mdpi.com/2077-0383/10/4/832

Internet

https://www.mdpi.com/2077-0383/10/4/832

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