Characterization of a new mouse model for human apolipoprotein A-I/C-III/A-IV deficiency

Characterization of a new mouse model for human apolipoprotein A-I/C-III/A-IV deficiency

Human data raised the possibility that coronary heart disease is associated with mutations in the apolipoprotein gene cluster APOA1/C3/A4 that result in multideficiency of cluster-encoded apolipoproteins and hypoalphalipoproteinemia. To test this hypothesis, we generated a mouse model for human apol...

Full description

Bibliographic Details
Main Authors: Hafid Mezdour, Guilhem Larigauderie, Graciela Castro, Gerard Torpier, Jamila Fruchart, Maxime Nowak, Jean-Charles Fruchart, Mustapha Rouis, Nobuyo Maeda
Format: Article
Language:English
Published: Elsevier 2006-05-01
Series:Journal of Lipid Research
Subjects:
apoa1/c3/a4 gene cluster (mouse)
APOA1/C3/A4 gene cluster (human)
knockout mouse
hypoalphalipoproteinemia
high-fat Western-type diet
atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520332399

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520332399

Similar Items