Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch SignalingSummary

Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch SignalingSummary

Background & Aims: Epithelial regeneration is essential for homeostasis and repair of the mucosal barrier. In the context of infectious and immune-mediated intestinal disease, interleukin (IL) 22 is thought to augment these processes. We sought to define the mechanisms by which IL22 promotes muc...

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Bibliographic Details
Main Authors: Juan-Min Zha, Hua-Shan Li, Qian Lin, Wei-Ting Kuo, Zhi-Hui Jiang, Pei-Yun Tsai, Ning Ding, Jia Wu, Shao-Fang Xu, Yi-Tang Wang, Jian Pan, Xiu-Min Zhou, Kai Chen, Min Tao, Matthew A. Odenwald, Atsushi Tamura, Sachiko Tsukita, Jerrold R. Turner, Wei-Qi He
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X18301280

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http://www.sciencedirect.com/science/article/pii/S2352345X18301280

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