MRI Analysis of White Matter Myelin Water Content in Multiple Sclerosis: A Novel Approach Applied to Finding Correlates of Cortical Thinning

MRI Analysis of White Matter Myelin Water Content in Multiple Sclerosis: A Novel Approach Applied to Finding Correlates of Cortical Thinning

A novel lesion-mask free method based on a gamma mixture model was applied to myelin water fraction (MWF) maps to estimate the association between cortical thickness and myelin content, and how it differs between relapsing-remitting (RRMS) and secondary-progressive multiple sclerosis (SPMS) groups (...

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Bibliographic Details
Main Authors: Michael Dayan, Sandra M. Hurtado Rúa, Elizabeth Monohan, Kyoko Fujimoto, Sneha Pandya, Eve M. LoCastro, Tim Vartanian, Thanh D. Nguyen, Ashish Raj, Susan A. Gauthier
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Neuroscience
Subjects:
multiple sclerosis
cortical thickness
white matter
myelin water fraction
RRMS
SPMS
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00284/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00284/full

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