Insulin Receptor Isoform A Modulates Metabolic Reprogramming of Breast Cancer Cells in Response to IGF2 and Insulin Stimulation

Insulin Receptor Isoform A Modulates Metabolic Reprogramming of Breast Cancer Cells in Response to IGF2 and Insulin Stimulation

Previously published work has demonstrated that overexpression of the insulin receptor isoform A (IR-A) might play a role in cancer progression and metastasis. The IR has a predominant metabolic role in physiology, but the potential role of IR-A in cancer metabolic reprogramming is unknown. We aimed...

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Bibliographic Details
Main Authors: Veronica Vella, Maria Luisa Nicolosi, Marika Giuliano, Andrea Morrione, Roberta Malaguarnera, Antonino Belfiore
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
insulin receptor isoform A
IGF2
IGF1R
metabolic reprogramming
aerobic glycolysis
metabolic flexibility
breast cancer
Online Access:https://www.mdpi.com/2073-4409/8/9/1017

Internet

https://www.mdpi.com/2073-4409/8/9/1017

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