Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation

Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation

Summary: Herpesviruses are ubiquitous in the human population and they extensively remodel the cellular environment during infection. Multiplexed quantitative proteomic analysis over the time course of herpes simplex virus 1 (HSV-1) infection was used to characterize changes in the host-cell proteom...

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Bibliographic Details
Main Authors: Timothy K. Soh, Colin T.R. Davies, Julia Muenzner, Leah M. Hunter, Henry G. Barrow, Viv Connor, Clément R. Bouton, Cameron Smith, Edward Emmott, Robin Antrobus, Stephen C. Graham, Michael P. Weekes, Colin M. Crump
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
herpesvirus
virus-host interaction
immune evasion
membrane trafficking
proteasomal degradation
quantitative proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312249

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http://www.sciencedirect.com/science/article/pii/S2211124720312249

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