Early auto‐immune targeting of photoreceptor ribbon synapses in mouse models of multiple sclerosis

Early auto‐immune targeting of photoreceptor ribbon synapses in mouse models of multiple sclerosis

Abstract Optic neuritis is one of the first manifestations of multiple sclerosis. Its pathogenesis is incompletely understood, but considered to be initiated by an auto‐immune response directed against myelin sheaths of the optic nerve. Here, we demonstrate in two frequently used and well‐validated...

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Bibliographic Details
Main Authors: Mayur Dembla, Ajay Kesharwani, Sivaraman Natarajan, Claudia Fecher‐Trost, Richard Fairless, Sarah K Williams, Veit Flockerzi, Ricarda Diem, Karin Schwarz, Frank Schmitz
Format: Article
Language:English
Published: Wiley 2018-11-01
Series:EMBO Molecular Medicine
Subjects:
CASPR1
multiple sclerosis
retina
ribbon synapse
RIBEYE
Online Access:https://doi.org/10.15252/emmm.201808926

Internet

https://doi.org/10.15252/emmm.201808926

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