Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level

Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level

<p>Abstract</p> <p>Background</p> <p>Fibrillar amyloid-like deposits and co-deposits of tau and α-synuclein are found in several common neurodegenerative diseases. Recent evidence indicates that small oligomers are the most relevant toxic aggregate species. While tau fi...

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Bibliographic Details
Main Authors: Nübling Georg, Bader Benedikt, Levin Johannes, Hildebrandt Jenna, Kretzschmar Hans, Giese Armin
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Molecular Neurodegeneration
Subjects:
α-Synuclein, Metal ion, Oligomer, Phosphorylation, Tau, Iron, Aluminium, GSK-3 beta, Alzheimer’s disease
Parkinson’s disease
Online Access:http://www.molecularneurodegeneration.com/content/7/1/35

Internet

http://www.molecularneurodegeneration.com/content/7/1/35

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