(2<i>R</i>,3<i>S</i>)-Dihydroxybutanoic Acid Synthesis as a Novel Metabolic Function of Mutant Isocitrate Dehydrogenase 1 and 2 in Acute Myeloid Leukemia
Acute myeloid leukemia (AML) frequently harbors mutations in isocitrate 1 (<i>IDH1</i>) and 2 (<i>IDH2</i>) genes, leading to the formation of the oncometabolite (2<i>R</i>)-hydroxyglutaric acid (2R-HG) with epigenetic consequences for AML proliferation and differ...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/10/2842 |