Polymorphism in ion channel genes of Dirofilaria immitis: Relevant knowledge for future anthelmintic drug design

Polymorphism in ion channel genes of Dirofilaria immitis: Relevant knowledge for future anthelmintic drug design

Dirofilaria immitis, a filarial parasite, causes cardiopulmonary dirofilariasis in dogs, cats and wild canids. The macrocyclic lactone (ML) class of drugs has been used to prevent heartworm infection. There is confirmed ML resistance in D. immitis and thus there is an urgent need to find new anthelm...

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Bibliographic Details
Main Authors: Thangadurai Mani, Catherine Bourguinat, Kathy Keller, Elena Carreton, Andrew Peregrine, Roger K. Prichard
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Dirofilaria immitis
Ion channels
Macrocyclic lactones
Loss of efficacy
Neuromuscular system
Single nucleotide polymorphism
Drug targets
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320716300185

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http://www.sciencedirect.com/science/article/pii/S2211320716300185

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