Oxidative Stress and Cardiovascular Complications in Chronic Kidney Disease, the Impact of Anaemia
Patients with chronic kidney disease (CKD) have significant cardiovascular morbidity and mortality as a result of risk factors such as left ventricular hypertrophy (LVH), oxidative stress, and inflammation. The presence of anaemia in CKD further increases the risk of LVH and oxidative stress, thereb...
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doaj-7378919e28d2411bbebe061ccf17cce72020-11-25T03:36:12ZengMDPI AGPharmaceuticals1424-82472018-10-0111410310.3390/ph11040103ph11040103Oxidative Stress and Cardiovascular Complications in Chronic Kidney Disease, the Impact of AnaemiaFaisal Nuhu0Sunil Bhandari1School of Life Sciences (Biomedical), University of Hull, Cottingham Rd, Hull HU6 7RX, UKHull York Medical School & Department of Renal Medicine, Hull and East Yorkshire NHS Hospital Trust, Hull HU3 2JZ, UKPatients with chronic kidney disease (CKD) have significant cardiovascular morbidity and mortality as a result of risk factors such as left ventricular hypertrophy (LVH), oxidative stress, and inflammation. The presence of anaemia in CKD further increases the risk of LVH and oxidative stress, thereby magnifying the deleterious consequence in uraemic cardiomyopathy (UCM), and aggravating progression to failure and increasing the risk of sudden cardiac death. This short review highlights the specific cardio-renal oxidative stress in CKD and provides an understanding of the pathophysiology and impact of uraemic toxins, inflammation, and anaemia on oxidative stress.http://www.mdpi.com/1424-8247/11/4/103oxidative stressanaemiacardiovascular diseasechronic kidney diseaseIV iron therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Faisal Nuhu Sunil Bhandari |
spellingShingle |
Faisal Nuhu Sunil Bhandari Oxidative Stress and Cardiovascular Complications in Chronic Kidney Disease, the Impact of Anaemia Pharmaceuticals oxidative stress anaemia cardiovascular disease chronic kidney disease IV iron therapy |
author_facet |
Faisal Nuhu Sunil Bhandari |
author_sort |
Faisal Nuhu |
title |
Oxidative Stress and Cardiovascular Complications in Chronic Kidney Disease, the Impact of Anaemia |
title_short |
Oxidative Stress and Cardiovascular Complications in Chronic Kidney Disease, the Impact of Anaemia |
title_full |
Oxidative Stress and Cardiovascular Complications in Chronic Kidney Disease, the Impact of Anaemia |
title_fullStr |
Oxidative Stress and Cardiovascular Complications in Chronic Kidney Disease, the Impact of Anaemia |
title_full_unstemmed |
Oxidative Stress and Cardiovascular Complications in Chronic Kidney Disease, the Impact of Anaemia |
title_sort |
oxidative stress and cardiovascular complications in chronic kidney disease, the impact of anaemia |
publisher |
MDPI AG |
series |
Pharmaceuticals |
issn |
1424-8247 |
publishDate |
2018-10-01 |
description |
Patients with chronic kidney disease (CKD) have significant cardiovascular morbidity and mortality as a result of risk factors such as left ventricular hypertrophy (LVH), oxidative stress, and inflammation. The presence of anaemia in CKD further increases the risk of LVH and oxidative stress, thereby magnifying the deleterious consequence in uraemic cardiomyopathy (UCM), and aggravating progression to failure and increasing the risk of sudden cardiac death. This short review highlights the specific cardio-renal oxidative stress in CKD and provides an understanding of the pathophysiology and impact of uraemic toxins, inflammation, and anaemia on oxidative stress. |
topic |
oxidative stress anaemia cardiovascular disease chronic kidney disease IV iron therapy |
url |
http://www.mdpi.com/1424-8247/11/4/103 |
work_keys_str_mv |
AT faisalnuhu oxidativestressandcardiovascularcomplicationsinchronickidneydiseasetheimpactofanaemia AT sunilbhandari oxidativestressandcardiovascularcomplicationsinchronickidneydiseasetheimpactofanaemia |
_version_ |
1724550484788772864 |