Effective inhibition of human immunodeficiency virus 1 replication by engineered RNase P ribozyme.

Effective inhibition of human immunodeficiency virus 1 replication by engineered RNase P ribozyme.

Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that efficiently cleave an mRNA sequence in vitro. In this study, a variant was used to target the HIV RNA sequence in the tat region. The variant cleaved the tat RNA sequence in vitro about 20 times more ef...

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Bibliographic Details
Main Authors: Wenbo Zeng, Yuan-Chuan Chen, Yong Bai, Phong Trang, Gia-Phong Vu, Sangwei Lu, Jianguo Wu, Fenyong Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3530568?pdf=render

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http://europepmc.org/articles/PMC3530568?pdf=render

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