Effective inhibition of human immunodeficiency virus 1 replication by engineered RNase P ribozyme.
Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that efficiently cleave an mRNA sequence in vitro. In this study, a variant was used to target the HIV RNA sequence in the tat region. The variant cleaved the tat RNA sequence in vitro about 20 times more ef...
Main Authors: | Wenbo Zeng, Yuan-Chuan Chen, Yong Bai, Phong Trang, Gia-Phong Vu, Sangwei Lu, Jianguo Wu, Fenyong Liu |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3530568?pdf=render |
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