A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation

A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation

ABSTRACT Bisphosphonates (BPs) are a mainstay of osteoporosis treatment; however, concerns about bone health based on oversuppression of remodeling remain. Long‐term bone remodeling suppression adversely affects bone material properties with microdamage accumulation and reduced fracture toughness in...

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Bibliographic Details
Main Authors: Abigail A Coffman, Jelena Basta‐Pljakic, Rosa M Guerra, Frank H Ebetino, Mark W Lundy, Robert J Majeska, Mitchell B Schaffler
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:JBMR Plus
Subjects:
ANALYSIS/QUANTITATION OF BONE
ANTIRESORPTIVES
BONE HISTOMORPHOMETRY
BONE MICRO‐COMPUTED TOMOGRAPHY (μCT)
BONE MODELING AND REMODELING
BONE QUANTITATIVE (QCT)
Online Access:https://doi.org/10.1002/jbm4.10476

Internet

https://doi.org/10.1002/jbm4.10476

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