Upregulation of the transcription factor TFAP2D is associated with aggressive tumor phenotype in prostate cancer lacking the TMPRSS2:ERG fusion

Upregulation of the transcription factor TFAP2D is associated with aggressive tumor phenotype in prostate cancer lacking the TMPRSS2:ERG fusion

Abstract Background TFAP2D is a transcription factor important for modulating gene expression in embryogenesis. Its expression and prognostic role in prostate cancer has not been evaluated. Methods Therefore, a tissue microarray containing 17,747 prostate cancer specimens with associated pathologica...

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Bibliographic Details
Main Authors: Christoph Fraune, Luisa Harms, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Till S. Clauditz, Ronald Simon, Katharina Möller, Andreas M. Luebke, Christina Möller-Koop, Stefan Steurer, Claudia Hube-Magg, Guido Sauter, Sören Weidemann, Patrick Lebok, David Dum, Simon Kind, Sarah Minner, Jakob R. Izbicki, Thorsten Schlomm, Hartwig Huland, Hans Heinzer, Eike Burandt, Alexander Haese, Markus Graefen, Cornelia Schroeder
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Molecular Medicine
Subjects:
TFAP2D
prostate cancer
genomic instability
prognosis
immunohistochemistry
tissue micro array
Online Access:http://link.springer.com/article/10.1186/s10020-020-00148-4

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http://link.springer.com/article/10.1186/s10020-020-00148-4

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