Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression

Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression

Abstract Background Oct4, a key stemness transcription factor, is overexpressed in lung cancer. Here, we reveal a novel transcription regulation of long non-coding RNAs (lncRNAs) by Oct4. LncRNAs have emerged as important players in cancer progression. Methods Oct4 chromatin-immunoprecipitation (ChI...

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Bibliographic Details
Main Authors: Jayu Jen, Yen-An Tang, Ying-Hung Lu, Che-Chung Lin, Wu-Wei Lai, Yi-Ching Wang
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Molecular Cancer
Subjects:
Oct4
lncRNA
MALAT1
NEAT1
Transcription regulation
Lung cancer
Online Access:http://link.springer.com/article/10.1186/s12943-017-0674-z

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http://link.springer.com/article/10.1186/s12943-017-0674-z

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