The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.

The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.

For nearly 20 years, the principal biological function of the HIV-2/SIV Vpx gene has been thought to be required for optimal virus replication in myeloid cells. Mechanistically, this Vpx activity was recently reported to involve the degradation of Sterile Alpha Motif and HD domain-containing protein...

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Main Authors: Masashi Shingai, Sarah Welbourn, Jason M Brenchley, Priyamvada Acharya, Eri Miyagi, Ronald J Plishka, Alicia Buckler-White, Peter D Kwong, Yoshiaki Nishimura, Klaus Strebel, Malcolm A Martin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4440783?pdf=render

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http://europepmc.org/articles/PMC4440783?pdf=render

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