Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Clp1K/K Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth

Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Clp1K/K Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth

Embryonic lungs must be inflated immediately after birth to establish respiration. In addition to pulmonary surfactant, recently, we have revealed lymphatic function as a previously unknown regulator of prenatal lung compliance that prepares the embryonic lung for inflation at birth. It is well-docu...

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Bibliographic Details
Main Authors: Kitti Szoták-Ajtay, Dániel Szõke, Gábor Kovács, Judit Andréka, Gábor B. Brenner, Zoltán Giricz, Josef Penninger, Mark L. Kahn, Zoltán Jakus
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
fetal breathing movements
pulmonary lymphatics
lung development
genetic mouse models
organ-specific lymphatic function
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00136/full

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https://www.frontiersin.org/article/10.3389/fbioe.2020.00136/full

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