Common DNA sequence variation influences 3-dimensional conformation of the human genome

Common DNA sequence variation influences 3-dimensional conformation of the human genome

Abstract Background The 3-dimensional (3D) conformation of chromatin inside the nucleus is integral to a variety of nuclear processes including transcriptional regulation, DNA replication, and DNA damage repair. Aberrations in 3D chromatin conformation have been implicated in developmental abnormali...

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Bibliographic Details
Main Authors: David U. Gorkin, Yunjiang Qiu, Ming Hu, Kipper Fletez-Brant, Tristin Liu, Anthony D. Schmitt, Amina Noor, Joshua Chiou, Kyle J. Gaulton, Jonathan Sebat, Yun Li, Kasper D. Hansen, Bing Ren
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-019-1855-4

Internet

https://doi.org/10.1186/s13059-019-1855-4

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