Efficacy of Fosfomycin and Its Combination With Aminoglycosides in an Experimental Sepsis Model by Carbapenemase-Producing Klebsiella pneumoniae Clinical Strains

Carbapenemase-producing Klebsiella pneumoniae infections are an increasing global threat with scarce and uncertain treatment options. In this context, combination therapies are often used for these infections. The bactericidal and synergistic activity of fosfomycin plus amikacin and gentamicin was s...

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Main Authors: Tania Cebrero-Cangueiro, Gema Labrador-Herrera, Álvaro Pascual, Caridad Díaz, Jesús Rodríguez-Baño, Jerónimo Pachón, José P. del Palacio, María E. Pachón-Ibáñez, M. Carmen Conejo
Format: Article
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.615540/full