Synthesis and Biological Evaluation of 3-Benzisoxazolyl-4-indolylmaleimides as Potent, Selective Inhibitors of Glycogen Synthase Kinase-3β

Synthesis and Biological Evaluation of 3-Benzisoxazolyl-4-indolylmaleimides as Potent, Selective Inhibitors of Glycogen Synthase Kinase-3β

A series of novel 3-benzisoxazolyl-4-indolyl-maleimides were synthesized and evaluated for their GSK-3β inhibitory activity. Most compounds exhibited high inhibitory potency towards GSK-3β. Among them, compound 7j with an IC50 value of 0.73 nM was the most promising GSK-3β inhibitor. Preliminary str...

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Bibliographic Details
Main Authors: Jianrong Gao, Weisi Wang, Yujin Li, Liang Han, Lei Xu, Jiayi Cao, Tao Pang, Yubo Zhou, Meng Li, Qing Ye, Jia Li
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Molecules
Subjects:
3-benzisoxazolyl-4-indolylmaleimides
synthesis
GSK-3β
biological activity
docking
SAR
Online Access:http://www.mdpi.com/1420-3049/18/5/5498

Internet

http://www.mdpi.com/1420-3049/18/5/5498

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