Development and validation of an in vitro–in vivo correlation (IVIVC) model for propranolol hydrochloride extended-release matrix formulations

The objective of this study was to develop an in vitro–in vivo correlation (IVIVC) model for hydrophilic matrix extended-release (ER) propranolol dosage formulations. The in vitro release characteristics of the drug were determined using USP apparatus I at 100 rpm, in a medium of varying pH (from pH...

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Bibliographic Details
Main Authors: Chinhwa Cheng, Pao-Chu Wu, Hsin-Ya Lee, Kuang-Yang Hsu
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Journal of Food and Drug Analysis
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S102194981300080X