Modulation of Microtubule Dynamics Affects Brucella abortus Intracellular Survival, Pathogen-Containing Vacuole Maturation, and Pro-inflammatory Cytokine Production in Infected Macrophages

Modulation of Microtubule Dynamics Affects Brucella abortus Intracellular Survival, Pathogen-Containing Vacuole Maturation, and Pro-inflammatory Cytokine Production in Infected Macrophages

The microtubule (MT) cytoskeleton regulates several cellular processes related to the immune system. For instance, an intricate intracellular transport mediated by MTs is responsible for the proper localization of vesicular receptors of innate immunity and its adaptor proteins. In the present study,...

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Bibliographic Details
Main Authors: Juliana Alves-Silva, Isabela P. Tavares, Erika S. Guimarães, Miriam M. Costa Franco, Barbara C. Figueiredo, João T. Marques, Gary Splitter, Sergio C. Oliveira
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Microbiology
Subjects:
Brucella abortus
microtubules
TcpB
innate immunity
bacterial pathogenesis
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.02217/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.02217/full

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