Paclitaxel-Loaded Nanosponges Inhibit Growth and Angiogenesis in Melanoma Cell Models

Paclitaxel-Loaded Nanosponges Inhibit Growth and Angiogenesis in Melanoma Cell Models

This study investigated the effects of free paclitaxel (PTX) and PTX-loaded in pyromellitic nanosponges (PTX-PNS) in reducing in vitro and in vivo melanoma cell growth and invasivity, and in inhibiting angiogenesis. To test the response of cells to the two PTX formulations, the cell viability was ev...

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Bibliographic Details
Main Authors: Nausicaa Clemente, Monica Argenziano, Casimiro Luca Gigliotti, Benedetta Ferrara, Elena Boggio, Annalisa Chiocchetti, Fabrizio Caldera, Francesco Trotta, Elisa Benetti, Laura Annaratone, Simone Ribero, Stefania Pizzimenti, Giuseppina Barrera, Umberto Dianzani, Roberta Cavalli, Chiara Dianzani
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
paclitaxel
melanoma
angiogenesis
tumor growth
mouse model
nanosponges
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00776/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00776/full

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