iNOS Activity Is Required for the Therapeutic Effect of Mesenchymal Stem Cells in Experimental Systemic Sclerosis

iNOS Activity Is Required for the Therapeutic Effect of Mesenchymal Stem Cells in Experimental Systemic Sclerosis

Objectives: Fibrosis is a hallmark of systemic sclerosis (SSc), an intractable disease where innovative strategies are still being sought. Among novel anti-fibrotic approaches, mesenchymal stromal/stem cell (MSC)-based therapy appears promising. Previously, we reported anti-fibrotic effects of MSC i...

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Bibliographic Details
Main Authors: Alexandre T. J. Maria, Pauline Rozier, Guillaume Fonteneau, Thibault Sutra, Marie Maumus, Karine Toupet, Jean-Paul Cristol, Christian Jorgensen, Philippe Guilpain, Danièle Noël
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
systemic sclerosis
HOCl
mesenchymal stem cells
inducible NO synthase
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03056/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03056/full

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