Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines

<p>Abstract</p> <p>Background</p> <p>One of the major reasons for poor prognosis of pancreatic cancer is its high resistance to currently available chemotherapeutic agents. In recent years, focal adhesion kinase (FAK), a central molecule in extracellular matrix (ECM)/in...

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Bibliographic Details
Main Authors: Kai Wang, Xinyu Ren, Xiaohua Shi, Zhiyong Liang, Huanwen Wu, Tonghua Liu
Format: Article
Language:English
Published: BMC 2009-12-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/8/1/125