Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening

Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening

Delivery of drugs and macromolecules to the central nervous system (CNS) is hindered by the blood–brain barrier (BBB). Several approaches have been used to overcome this hindrance to facilitate the treatment of various CNS diseases. We now present results showing that chimeric adeno-associated virus...

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Bibliographic Details
Main Authors: Angelika Alonso, Eileen Reinz, Barbara Leuchs, Jürgen Kleinschmidt, Marc Fatar, Bart Geers, Ine Lentacker, Michael G. Hennerici, Stefaan C. de Smedt, Stephen Meairs
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
AAV
blood–brain barrier
ultrasound
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301329

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http://www.sciencedirect.com/science/article/pii/S2162253116301329

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