A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging

A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging

Neuromodulators have profound effects on behavior, but the dynamics of their intracellular effectors has remained unclear. Most neuromodulators exert their function via G-protein-coupled receptors (GPCRs). One major challenge for understanding neuromodulator action is the lack of dynamic readouts o...

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Bibliographic Details
Main Authors: Yao eChen, Jessica Lizette Saulnier, Gary eYellen, Bernardo eSabatini
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Pharmacology
Subjects:
Glutamate
Neuromodulation
dendritic spine
cAMP
GPCR
PKA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00056/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00056/full

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