Ornithine Transcarbamylase – From Structure to Metabolism: An Update

Ornithine Transcarbamylase – From Structure to Metabolism: An Update

Ornithine transcarbamylase (OTC; EC 2.1.3.3) is a ubiquitous enzyme found in almost all organisms, including vertebrates, microorganisms, and plants. Anabolic, mostly trimeric OTCs catalyze the production of L-citrulline from L-ornithine which is a part of the urea cycle. In eukaryotes, such OTC loc...

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Bibliographic Details
Main Authors: Morgane Couchet, Charlotte Breuillard, Christelle Corne, John Rendu, Béatrice Morio, Uwe Schlattner, Christophe Moinard
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Physiology
Subjects:
OTC deficiency
liver
intestine
NASH
diabetes
citrulline
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.748249/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.748249/full

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