Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice.

Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice.

Superagonistic CD28-specific monoclonal antibodies (CD28SA) are highly effective activators of regulatory T-cells (Treg cells) in rats, but a first-in-man trial of the human CD28SA TGN1412 resulted in an unexpected cytokine release syndrome. Using a novel mouse anti-mouse CD28SA, we re-investigate t...

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Bibliographic Details
Main Authors: Tea Gogishvili, Daniela Langenhorst, Fred Lühder, Fernando Elias, Karin Elflein, Kevin M Dennehy, Ralf Gold, Thomas Hünig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2645706?pdf=render

Internet

http://europepmc.org/articles/PMC2645706?pdf=render

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