Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds

Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds

The inhibitory activity of 14 racemic phosphonic acid analogs of phenylglycine, substituted in aromatic rings, towards porcine aminopeptidase N (pAPN) and barley seed aminopeptidase was determined experimentally. The obtained patterns of the inhibitory activity against the two enzymes were similar....

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Bibliographic Details
Main Authors: Weronika Wanat, Michał Talma, Małgorzata Pawełczak, Paweł Kafarski
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Pharmaceuticals
Subjects:
aminopeptidases
inhibitors
aminophosphonate
phenylglycine analogues
fluorine substituted
molecular modeling
Online Access:https://www.mdpi.com/1424-8247/12/3/139

Internet

https://www.mdpi.com/1424-8247/12/3/139

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