Cirrhotic Endothelial Progenitor Cells Enhance Liver Angiogenesis and Fibrosis and Aggravate Portal Hypertension in Bile Duct-Ligated Cirrhotic Rats

Cirrhotic Endothelial Progenitor Cells Enhance Liver Angiogenesis and Fibrosis and Aggravate Portal Hypertension in Bile Duct-Ligated Cirrhotic Rats

BackgroundCirculating cirrhotic endothelial progenitor cells (EPC) interact with both liver sinusoidal endothelial cells (LSEC) and hepatic stellate cells (HSC) and promote angiogenesis in vitro. This study evaluated the effect of cirrhotic and control EPCs on hepatic angiogenesis, microcirculation,...

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Bibliographic Details
Main Authors: Dinesh Mani Tripathi, Mohsin Hassan, Hamda Siddiqui, Impreet Kaur, Preety Rawal, Chaggan Bihari, Savneet Kaur, Shiv K. Sarin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Physiology
Subjects:
endothelial progenitor cells
fibrosis
angiogenesis
portal hypertension
cell transplant
vascular endothelial growth factor
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00617/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00617/full

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