Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway

Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway

Abstract Background m6A modification has been proved to play an important role in many biological processes. METTL3 as the main methyltransferase for methylation process has been found to be upregulated in many cancers, including CRC. Here, we investigate m6A modification and the underlying mechanis...

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Bibliographic Details
Main Authors: Wen Peng, Jie Li, Ranran Chen, Qiou Gu, Peng Yang, Wenwei Qian, Dongjian Ji, Qingyuan Wang, Zhiyuan Zhang, Junwei Tang, Yueming Sun
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
m6A modification
METTL3
miR-1246
Tumor invasion
CRC
Online Access:http://link.springer.com/article/10.1186/s13046-019-1408-4

Internet

http://link.springer.com/article/10.1186/s13046-019-1408-4

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