Increased Circulatory Asymmetric Dimethylarginine and Multiple Organ Failure: Bile Duct Ligation in Rat as a Model

Increased Circulatory Asymmetric Dimethylarginine and Multiple Organ Failure: Bile Duct Ligation in Rat as a Model

Bile duct ligation (BDL)-treated rats exhibit cholestasis, increased systemic oxidative stress, and liver fibrosis, which ultimately lead to liver cirrhosis. Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of nitric oxide synthase that can decrease the synthesis of nitric oxide. BDL ra...

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Bibliographic Details
Main Authors: Jiunn-Ming Sheen, Yu-Chieh Chen, You-Lin Tain, Li-Tung Huang
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:International Journal of Molecular Sciences
Subjects:
asymmetric dimethylarginine
bile duct ligation
cholestasis
oxidative stress
multiple organ failure
Online Access:http://www.mdpi.com/1422-0067/15/3/3989

Internet

http://www.mdpi.com/1422-0067/15/3/3989

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