Increased Circulatory Asymmetric Dimethylarginine and Multiple Organ Failure: Bile Duct Ligation in Rat as a Model
Bile duct ligation (BDL)-treated rats exhibit cholestasis, increased systemic oxidative stress, and liver fibrosis, which ultimately lead to liver cirrhosis. Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of nitric oxide synthase that can decrease the synthesis of nitric oxide. BDL ra...
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doaj-73a9cc3f9fab4947807eb3c4b1a429bc2020-11-25T02:30:51ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-03-011533989400610.3390/ijms15033989ijms15033989Increased Circulatory Asymmetric Dimethylarginine and Multiple Organ Failure: Bile Duct Ligation in Rat as a ModelJiunn-Ming Sheen0Yu-Chieh Chen1You-Lin Tain2Li-Tung Huang3Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanBile duct ligation (BDL)-treated rats exhibit cholestasis, increased systemic oxidative stress, and liver fibrosis, which ultimately lead to liver cirrhosis. Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of nitric oxide synthase that can decrease the synthesis of nitric oxide. BDL rats have higher plasma and hepatic ADMA levels, which may be due to increased hepatic protein arginine methyltransferase-1 and decreased dimethylarginine dimethylaminohydrolase expression. BDL rats also exhibit renal and brain damage characterized by increased tissue ADMA concentrations. The increased plasma ADMA levels and multiple organ damages seen here are also observed following multiple organ failures associated with critical illness. This review discusses the dysregulation of ADMA in major organs in BDL rats and the role of increased ADMA in multiple organ damages.http://www.mdpi.com/1422-0067/15/3/3989asymmetric dimethylargininebile duct ligationcholestasisoxidative stressmultiple organ failure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiunn-Ming Sheen Yu-Chieh Chen You-Lin Tain Li-Tung Huang |
spellingShingle |
Jiunn-Ming Sheen Yu-Chieh Chen You-Lin Tain Li-Tung Huang Increased Circulatory Asymmetric Dimethylarginine and Multiple Organ Failure: Bile Duct Ligation in Rat as a Model International Journal of Molecular Sciences asymmetric dimethylarginine bile duct ligation cholestasis oxidative stress multiple organ failure |
author_facet |
Jiunn-Ming Sheen Yu-Chieh Chen You-Lin Tain Li-Tung Huang |
author_sort |
Jiunn-Ming Sheen |
title |
Increased Circulatory Asymmetric Dimethylarginine and Multiple Organ Failure: Bile Duct Ligation in Rat as a Model |
title_short |
Increased Circulatory Asymmetric Dimethylarginine and Multiple Organ Failure: Bile Duct Ligation in Rat as a Model |
title_full |
Increased Circulatory Asymmetric Dimethylarginine and Multiple Organ Failure: Bile Duct Ligation in Rat as a Model |
title_fullStr |
Increased Circulatory Asymmetric Dimethylarginine and Multiple Organ Failure: Bile Duct Ligation in Rat as a Model |
title_full_unstemmed |
Increased Circulatory Asymmetric Dimethylarginine and Multiple Organ Failure: Bile Duct Ligation in Rat as a Model |
title_sort |
increased circulatory asymmetric dimethylarginine and multiple organ failure: bile duct ligation in rat as a model |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2014-03-01 |
description |
Bile duct ligation (BDL)-treated rats exhibit cholestasis, increased systemic oxidative stress, and liver fibrosis, which ultimately lead to liver cirrhosis. Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of nitric oxide synthase that can decrease the synthesis of nitric oxide. BDL rats have higher plasma and hepatic ADMA levels, which may be due to increased hepatic protein arginine methyltransferase-1 and decreased dimethylarginine dimethylaminohydrolase expression. BDL rats also exhibit renal and brain damage characterized by increased tissue ADMA concentrations. The increased plasma ADMA levels and multiple organ damages seen here are also observed following multiple organ failures associated with critical illness. This review discusses the dysregulation of ADMA in major organs in BDL rats and the role of increased ADMA in multiple organ damages. |
topic |
asymmetric dimethylarginine bile duct ligation cholestasis oxidative stress multiple organ failure |
url |
http://www.mdpi.com/1422-0067/15/3/3989 |
work_keys_str_mv |
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