Genotoxicity of the cyclo-oxygenase-inhibitor sulindac sulfide in the filamentous fungus Aspergillus nidulans Genotoxicidade de sulfeto de sulindaco em Aspergillus nidulans

Genotoxicity of the cyclo-oxygenase-inhibitor sulindac sulfide in the filamentous fungus Aspergillus nidulans Genotoxicidade de sulfeto de sulindaco em Aspergillus nidulans

Sulindac sulfide is a non-steroidal anti-inflammatory drug (NSAID) with chemopreventive effect on human cancer cells. Due to the involvement of the somatic recombination in the carcinogenic process, sulindac sulfide's recombinogenic potential was evaluated by the Homozygotization Index (HI) in...

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Bibliographic Details
Main Authors: Claudinéia Conationi da Silva Franco, Claudia Tiemi Miyamoto, Juliane Rocha de Sant'Anna, Marialba Avezum Alves de Castro-Prado
Format: Article
Language:English
Published: Sociedade Brasileira de Microbiologia 2007-09-01
Series:Brazilian Journal of Microbiology
Subjects:
agentes antineoplásicos
crossing-over mitótico
malignidade secundária
recombinação somática
antineoplastic agents
mitotic crossing-over
secondary malignances
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000300009

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000300009

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